Experiment 3: Uniformity of Weight of Tablets and Capsules
Tablets:
1. 20 tablets were selected
randomly and weighed. The average weight was determined.
2. The tablets were weighed
individually and for each tablet, the percentage deviation of its weight from
the average weight was determined.
3. The deviation of
individual weight from the average weight should not exceed the limits given
below.
Average weight of tablet
|
Deviation (%)
|
Number of tablets
|
Less than 80 mg
|
±10.0
±20.0
|
Minimum 18
Maximum 2
|
80 mg to 250 mg
|
±7.5
±15.0
|
Minimum 18
Maximum 2
|
More than 250 mg
|
±5.0
±10.0
|
Minimum 18
Maximum 2
|
Results:
Total weight of 20 tablets =
11.7097 g
Average weight = 0.5855 g
No.
|
Individual weight of tablets (g)
|
Percentage of deviation (%)
|
1.
|
0.6006
|
+2.58
|
2.
|
0.5853
|
-0.03
|
3.
|
0.5791
|
-1.09
|
4.
|
0.5875
|
+0.34
|
5.
|
0.5788
|
-1.14
|
6.
|
0.5878
|
+0.39
|
7.
|
0.5907
|
+0.89
|
8.
|
0.5880
|
+0.43
|
9.
|
0.5912
|
+0.97
|
10.
|
0.5906
|
+0.87
|
11.
|
0.5867
|
+0.20
|
12.
|
0.5944
|
+1.52
|
13.
|
0.5764
|
-1.55
|
14.
|
0.5551
|
-5.19
|
15.
|
0.5956
|
+1.73
|
16.
|
0.5826
|
-0.50
|
17.
|
0.5730
|
-2.13
|
18.
|
0.5845
|
-0.17
|
19.
|
0.5699
|
-2.66
|
20.
|
0.5721
|
-2.29
|
Capsules:
1. 20 capsules were selected
at random.
2. One capsule was weighed.
The capsule was then opened and the contents were removed as completely as
possible. The emptied shells were weighed. The net weight of its contents was
determined, that is by subtracting the weight of the shells from the weight of
the intact capsule.
3. The procedure was
repeated with the other 19 capsules.
4. The average net weight
was determined from the sum of the individual net weights.
5. The percentage deviation
was determined from the average net weight for each capsule. The deviation of
individual net weight should not exceed the limits given below.
Average net weight of capsule
|
Deviation (%)
|
Number of tablets
|
Less than 300 mg
|
±10.0
±20.0
|
Minimum 18
Maximum 2
|
300 mg or more
|
±7.5
±15.0
|
Minimum 18
Maximum 2
|
Results:
No.
|
Individual weight of capsules (g)
|
Weight of emptied shells (g)
|
Net weight of the contents (g)
|
Percentage deviation (%)
|
1.
|
0.4556
|
0.0705
|
0.3851
|
-1.36
|
2.
|
0.4455
|
0.0743
|
0.3712
|
-4.92
|
3.
|
0.4413
|
0.0753
|
0.3660
|
-6.25
|
4.
|
0.4683
|
0.0760
|
0.3923
|
+0.49
|
5.
|
0.4737
|
0.0779
|
0.3958
|
+1.38
|
6.
|
0.4645
|
0.0741
|
0.3904
|
0.00
|
7.
|
0.4684
|
0.0734
|
0.3950
|
+1.18
|
8.
|
0.4738
|
0.0760
|
0.3978
|
+1.90
|
9.
|
0.4715
|
0.0756
|
0.3959
|
+1.41
|
10.
|
0.4684
|
0.0751
|
0.3933
|
+0.74
|
11.
|
0.4621
|
0.0757
|
0.3864
|
-1.02
|
12.
|
0.4820
|
0.0817
|
0.4003
|
+2.54
|
13.
|
0.4719
|
0.0738
|
0.3981
|
+1.97
|
14.
|
0.4628
|
0.0780
|
0.3848
|
-1.43
|
15.
|
0.4773
|
0.0672
|
0.4101
|
+5.05
|
16.
|
0.4526
|
0.0718
|
0.3808
|
-2.50
|
17.
|
0.4662
|
0.0730
|
0.3932
|
+0.72
|
18.
|
0.4654
|
0.0758
|
0.3896
|
-0.20
|
19.
|
0.4678
|
0.0752
|
0.3926
|
+0.56
|
20.
|
0.4672
|
0.0788
|
0.3884
|
-0.51
|
Total net weight of the
content of 20 capsules = 7.8071 g
Average net weight = 0.3904 g
No comments:
Post a Comment