Experiment 2: Tablet Friability
Aims: to study the ability of the tablet to withstand abrasion in packaging, handling and shipping by the use of the Roche friabilator.
Apparatus and Materials: a Roche friabilator and 10 tablets of Uphamol cold and flu.
Procedure:
1)10 tablets of Uphamol cold & flu are selected and weighed.
2) All tablets are putted into the drum of the tablet abration and friability tester. The rate of rotation is set to 25rpm for 10 minutes and the operation is started.
3) At the end of the operation, all the tablets are removed and freedom from dust or powder is ensured by using the brush. The tablets are reweighed. The percentage loss of weight is determined.
4) Note that the compress tablet should not lose more than 1% of its weight.
Results:
Weight (g)
Drugs
|
Before experiment
|
After experiment
|
Uphamol cough and flu tablets(10 tablets)
|
6.40023g
|
6.3532g
|
Calculation:
Percentage loss of weight= (g)before experiment – (g) after experiment x 100%
(g) before experiment
= 6.40023-6.3532 x100%
6.40023
= 0.73%
Discussion:
This experiment is carried out in order to ensure how much the tablets can withstand the abrasion in packaging, handling and shipping. It is usually measured by the use of the Roche friabilator. A maximum weight loss of not more than 1% of the weight of the tablets being tested is considered generally acceptable and any broken or smashed tablets are not picked up. Normally, when capping occurs, friability values are not calculated. A thick tablet may have less tendency to cap whereas thin tablets of large diameter often show extensive capping, thus indicating that tablets with greater thickness have reduced internal stress.
Based on our results, we can say that the quality of the tablets is good because the percentage of weight loss is 0.73% and it is not exceeded 1%. Thus our experiment is success. Note that in some circumstances we may get the results of more than 1% because friability is depending on several factors such as:
1) Punches that are in poor condition or worn at their surface edges, resulting in 'whiskering' at the tablet edge and show higher than normal friability values.
2) Friability test is influenced by internal factors like the moisture content of tablet granules and finished tablets. Moisture at low and acceptable level acts as a binder.
Conclusion:
Based on our results we can say that the experiment is success as we could get the percent loss of weight not more than 1% that is 0.73% only. The tablets is said to be in a good quality as it’s not easily being broke and it can withstand incoming force.
References:
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